630559, Koltsovo village, Novosibirsk region

tel: (3832) 36-60-10

fax: (3832) 36-74-09

e-mail:

http://www.vector.nsc.ru

State Research Center of Virology and Biotechnology "Vector" (State Research Center VB "Vector") is one of the largest research and production complexes in Russia. The main activities of the Center are fundamental research in a wide area of ​​natural sciences and the development and production of therapeutic, prophylactic and diagnostic drugs.

Fundamental research work of the Center is focused on obtaining new scientific knowledge in the field of molecular biology, virology, genetic engineering, biotechnology, epidemiology and ecology in order to use them in the interests of the national economy.

The history of the establishment of the SSC VB "Vector" begins in 1974, when the head institute of the Center at that time, the All-Union Scientific Research Institute of Molecular Biology, was formed. In 1985, on its basis, the Research and Production Association "Vector" was created, which in 1994 received the status of the State Research Center.

Currently, the State Research Center for Virology and Biotechnology "Vector" unites a number of research institutes, industrial structures and other organizations. In addition, the Center is an associate member of a number of unions and associations.

The main asset of the Center is a unique laboratory and experimental base, which has no analogues in Russia, which allows conducting research with viruses pathogenic for humans and animals in complete safety for personnel and the environment. Highly qualified engineering, technical and scientific personnel have extensive experience working with especially dangerous viruses in the field of virology, molecular biology, genetic and cell engineering, biotechnology, ecology and epidemiology.

As of April 1, 2000, the Center employs 1,842 employees, of whom 901 people are engaged in scientific research, including 17 doctors and 147 candidates of sciences.

The training of highly qualified personnel is provided by the postgraduate study created at the Center in 1983, open in three specialties: molecular biology, virology and biotechnology. The SSC VB "Vector" has a dissertation council (D 208.020.01), in which 19 doctoral and 129 master's theses have been defended in the above specialties.

One of the Center's tasks is to provide the Novosibirsk region with preparations from donated blood, including anti-tick immunoglobulin. In close contact with city clinics, work is underway to diagnose a number of infectious diseases (viral hepatitis A, B, C, D, AIDS, cytomegalovirus, herpes and toxoplasma infections) and to expand the scope of antiviral drugs developed at the Vector State Research Center.

In recent years, the Novosibirsk administration has financed a number of innovative projects of the State Scientific Center of VB "Vector" related to the development of immunobiological and medical drugs.

History of SSC VB "Vector"

1974 - On the basis of the Government Decree on the development of molecular biology and biotechnology, the All-Union Scientific Research Institute of Molecular Biology (VNII MB) was established by the order of the Main Directorate of the Microbiological Industry under the Council of Ministers of the USSR (No. 1683 dated 02.08.74). The main task assigned to the Institute in those years was to study the fundamental features of the structure and function of especially dangerous viruses (ALE), experimental study of the pathogenesis of ALE, the study of the natural variability of specific viruses based on the analysis of the primary structure of their isolates obtained from different regions of the world, with the purpose of predicting the possibility of the emergence of new pathogens pathogenic for humans. In terms of application, the VNII MB was tasked with developing vaccine and diagnostic preparations using the latest advances in genetic engineering.

The All-Union Production Association "Biopreparat" made a decisive contribution to the creation and organization of VNII MB. With the direct participation of professors V.I. Ogarkova, V.D. Belyaeva, Yu.T. Kalinin, A.A. Vorobieva, I.V. Nikonova, L.A. Klyucharev, the laboratory and experimental base of the VNII MB was created.

An important role in the creation and development of the VNII MB was played by the Siberian branch of the USSR Academy of Sciences. Academicians M.A. Lavrent'ev, G.I. Marchuk, D.K. Belyaev, D.K. Knorre. VNII MB was provided with temporary space in Akademgorodok, where, during the first 4 years, scientific work was carried out in close cooperation with the Novosibirsk Institute of Bioorganic Chemistry, the Institute of Organic Chemistry, the Institute of Cytology and Genetics. These close scientific ties have survived to this day.

1985 - The Research and Production Association "Vector" (NPO "Vector") was created, which included VNII MB, NIKTI BAV (Research Design and Technological Institute of Biologically Active Substances), OPSP (Experimental Production Agricultural Enterprise) and NOPB (Scientific experimental industrial base).

1994 - By the Decree of the Government of the Russian Federation of March 29, 94, No. 247 NPO "Vector" was assigned the status of the State Scientific Center of the Russian Federation - State Research Center of Virology and Biotechnology "Vector". By order of the Ministry of Healthcare of the Russian Federation of October 21, 94, No. 210, the Charter of the state federal enterprise State Research Center of Virology and Biotechnology "Vector" of the Ministry of Health and Medical Industry of the Russian Federation was approved.

1998 - Order of the Ministry of Health of the Russian Federation dated 12.02.98 No. 40 approved amendments and additions to the Charter of the State Unitary Enterprise State Research Center of Virology and Biotechnology "Vector" of the Ministry of Health of the Russian Federation.

1999 - Received a certificate of the Ministry of Science and Technology of the Russian Federation on the state accreditation of a scientific organization State Unitary Enterprise State Research Center of Virology and Biotechnology "Vector" of the Ministry of Health of the Russian Federation dated April 22, 1999, No. 1091.

At present, the State Research Center for Virology and Biotechnology "Vector" is a large research and production complex, which includes six research institutes, four subsidiaries, a branch (NIKTI BAV) and a number of other separate structural divisions.

Structure of SSC VB "Vector"

Research Institute of Molecular Biology

(Director - Corresponding Member of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor S.V. Netesov)

• Fundamental and exploratory research in the field of classical and molecular virology, aimed at obtaining new scientific knowledge with the subsequent prospect of their use in the development of therapeutic, prophylactic and diagnostic drugs for the needs of public health and veterinary medicine.
• Study of the molecular diversity of human and animal viruses.
• Study of the evolution of the most dangerous viral pathogens in humans and animals, incl. at the molecular level, and the development of a methodology for the control of viral diseases.
• Molecular epidemiological studies of viral infection transmission routes.
• Applied research on the development of therapeutic, diagnostic and prophylactic drugs for medicine and veterinary medicine.
• Study of the mechanisms of functioning of genomes and proteins of pro- and eukaryotes.

Research Institute of Bioengineering

(Director - Doctor of Biological Sciences, Professor A.A.Ilyichev)

Main directions of activity:

• Construction of systems for the expression of heterologous genes in microbial cells to create on their basis producers of proteins of biomedical interest.
• Creation by protein engineering methods of protein variants with improved properties for their production and use in medical practice.
• Using phage display technology for mapping antigenic determinants of viral proteins, obtaining functional mimetics of antigenic determinants, constructing recombinant antibodies against human and animal pathogens.
• Development of principles and methodological approaches for the design of vaccines against viral diseases.
• Development of diagnostic test systems, including those based on molecular hybridization and amplification of nucleic acids, for use in medicine and veterinary medicine.
• Study of the structural and functional organization of viral genomes of farm animals.
• Study of the mechanisms of realization of the biostimulating and reparative action of chitosan at the cellular level.
• Organization of production of Hitogel preparations on the basis of SSC VB "Vector".
• Study of the interaction of recombinant filamentous phages with surface receptors of cells in order to select recombinant variants that specifically interact with cancer cells.
• Using phage display technology to diagnose early stages of atherosclerosis.
• Development of methods for rapid determination of M. tuberculosis resistance and investigation of the causes of its occurrence.
• Study by molecular biological methods of M. tuberculosis isolates circulating in the West Siberian region and creation of their representative collection.
• Study of the factors influencing the effectiveness of immunoprophylaxis of tuberculosis, and identification of possible ways to improve the vaccine.

Research Institute "Collection of Cultures and Microorganisms"

(Director - Candidate of Biological Sciences V.E. Repin)

Main directions of activity:

• Isolation, typing and storage of viral and bacterial strains, strains of producers of biologically active substances, genetically marked strains and genetic constructs obtained in domestic and foreign laboratories.
• Study of the properties of newly obtained strains, including genetically modified variants of previously known strains; their certification, including using the method of genomic fingerprinting; deposition and storage.
• Obtaining strains of microorganisms for use in the interests of the environment.
• Development of technology for obtaining viral, bacterial and fungal entomopathogenic drugs.
• Maintaining and studying the national collection of variola virus strains.

Research Institute of Cell Culture

(Director - Candidate of Medical Sciences E.A. Nechaeva)

Main directions of activity:

• Replenishment and maintenance of the cell culture bank of vertebrates, insects and plants, certification of lines and strains.
• Obtaining and certification of new lines and productive clones.
• Receiving and storage of seed and working banks of cultures of cells-producers of biologically active substances, their certification in accordance with the requirements of the WHO.
• Provision of experimental-industrial developments, research and experimental work of the State Research Center VB "Vector" with transplantable and primary cell cultures.
• Development and implementation into practice of new technologies for the production of drugs using cell engineering technology.
• Development, improvement and implementation of new technologies for the preparation of vaccine preparations using cell cultures and ways of delivering the vaccine to a living organism; development of new forms of their application.
• Development of technology for obtaining human cells for skin restoration.
• Development of technology for the production of hyaluronic acid.
• Live measles vaccine production.
• Production of nutrient media for the cultivation of cells and viruses.
• Production of solutions "Gemovekt" for use in hemodialysis and "Transvect" for storage of transplants.
• Serum production of cattle and horses.

Research Institute of Aerobiology

(Director - Candidate of Technical Sciences V.S.Toporkov)

The main activities of the Institute are related to fundamental and applied research in the field of ecology, medicine and health care. The Institute conducts bioaerosol research in the interests of medicine, virology and ecology. Also, the development of modern technologies for the production of therapeutic, prophylactic and diagnostic drugs for the needs of public health and veterinary medicine, the development of new instrumental methods for studying biological and bioaerosol systems is underway. Research areas include:

• theoretical and experimental study of the spread of aerosol pollution and bioaerosols in the atmosphere, their impact on public health and the development of preventive measures for areas with an unfavorable environmental situation;
• development of new methods and means of specific prevention;
• development of new types of samplers and equipment for the identification of biogenic components in aerosol impurities;
• development of new methodological approaches for express diagnostics of the sensitivity of microorganisms to allergens and drugs.

WHO Collaborating Center for Diagnosis of Orthopoxvirus Infections and Museum of Smallpox Virus Strains and DNA

(Head - Academician of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor L.S. Sandakhchiev)

Laboratory animal nursery

(director - V.N.Bondarenko)

Subsidiaries:

Subsidiary state unitary experimental production enterprise "Vector-BiAlgam"

(director - L. G. Nikulin)

"Vector-BiAlgam" is one of the leading enterprises in the development and production of immunobiological products and bifid-containing drugs and products.

• More than 20 enterprises of the dairy industry operate using Vector-BiAlgam technologies, including OOO Siberian Milk (Novosibirsk), OOO Siberian Milk Company (Kemerovo);
• A new promising strain of bifidobacteria was patented in Russia and confirmed by the Eurasian patent;
• By orders of the Ministry of Health of the Russian Federation, the Ministry of Justice of the Russian Federation and the Ministry of Internal Affairs of the Russian Federation, deliveries of hepatitis A vaccine are carried out;
• Within the framework of the new project, a mini-plant for the production of baby bifidus-containing food is being built;
• Divaccine for hepatitis A and B has been developed and is undergoing clinical trials.

Subsidiary state unitary manufacturing enterprise "Vector-Pharm"

(Director - Candidate of Physical and Mathematical Sciences S.N. Targonsky)

Main directions of activity:

• Production of medical and diagnostic products developed at the Center.
• Launching the production of healthcare products using technologies developed by third-party organizations.
• Production of finished dosage forms in cooperation with foreign firms and companies.
• Storage and sale of products manufactured by the Center.

Subsidiary state unitary experimental-industrial agricultural enterprise "Vector-OPSP"

(director - D.N. Loktionov)

Main directions of activity:

• Development of technology for the cultivation of medicinal herbs.
• Breeding marals to get antlers.
• Creation of an experimental base for obtaining bovine serum.
• Procurement of feed for keeping laboratory animals.

Branches acting on the basis of the provisions

Research Design and Technological Institute of Biologically Active Substances (NIKTI BAV)

(Director - Doctor of Biological Sciences V.I.Masycheva)

Main directions of activity:

• Creation of methods for obtaining products of modern biotechnology: recombinant cytokines and mutant variants of recombinant proteins, nucleic acids.
• Conducting preclinical trials of drugs for medical and veterinary purposes.
• Development of technologies for obtaining substances and dosage forms for the prevention and treatment of immunodeficient, oncological and infectious diseases in humans and animals.
• Creation of molecular constructs for targeted delivery of protein and genetic material.
• Development of diagnostic test systems for detecting infectious diseases.

The Federal Budgetary Institution of Science "State Research Center for Virology and Biotechnology" Vector "of the Federal Service for Surveillance on Consumer Rights Protection and Human Welfare is one of the largest scientific virological and biotechnological centers in Russia.

The mission of the Center is scientific and practical support for countering global infectious threats.

The Center was organized in 1974. It includes a branch - the Institute of Medical Biotechnology, located in the city of Berdsk, Novosibirsk Region.

Today, the fundamental research work of the SSC VB "Vector" is focused on obtaining new scientific knowledge in the field of epidemiology, molecular biology, virology, bacteriology, genetic engineering, biotechnology, ecology and biological safety. Applied research of the Center is aimed at the development of effective means and methods for the prevention, treatment and diagnosis of infectious diseases, the creation and improvement of biotechnologies for the production of means of counteracting infectious pathogens.

The main tasks facing the Center:

• fundamental research of pathogens of especially dangerous and socially significant viral infections, their genetic variability and diversity, the pathogenesis of viral infections;
• ensuring constant readiness for diagnostics of especially dangerous infectious agents;
• development and implementation of diagnostic, therapeutic and prophylactic means into healthcare practice;
• postgraduate training of specialists, as well as training of highly qualified scientific personnel in the field of virology, molecular biology and biotechnology through postgraduate studies and competition.

One of the first in Russia SSC VB "Vector" carried out the development and production of test systems for the diagnosis of HIV infection and hepatitis B; was the first in Russia to organize the production of genetically engineered human interferon-a-2; developed and introduced into production the immunostimulating drug Ridostin, which has antiviral activity, including against influenza; Together with the Institute of Poliomyelitis and Viral Encephalitis of the Russian Academy of Medical Sciences, he developed the only domestic vaccine against viral hepatitis A and introduced it into production.

In the main areas of scientific activity SSC VB "Vector" actively cooperates with various institutions of the Russian Academy of Sciences, RAMS, RAAS, Rospotrebnadzor, the Ministry of Health and Social Development and the Ministry of Emergencies of Russia.

SSC VB "Vector" carries out international partnership in the field of molecular epidemiology, virology, biosafety with leading scientific foreign centers. Cooperation with the CIS countries in the field of avian influenza monitoring is expanding. In 2006-2007. Rospotrebnadzor signed agreements on cooperation in the field of diagnostics and monitoring of influenza viruses with the Ministries of Health of Ukraine, Kazakhstan, Belarus, Uzbekistan and Azerbaijan. It is planned to conclude similar agreements with all CIS countries by the end of 2007. In addition, agreements on cooperation have been concluded between the national influenza centers of Russia, Kazakhstan and Ukraine. On their basis, joint expeditions and studies of the isolated strains of the influenza virus, the exchange of information, strains, and specialists are already underway and will continue to be carried out. It is planned to organize trainings both at the SSC VB "Vector" and the Central Research Institute of Epidemiology of Rospotrebnadzor, as well as in the countries participating in agreements and contracts.

Since 1997, one of the two WHO Collaborating Centers for the Diagnosis of Orthopoxvirus Infections and the Museum of Smallpox Virus Strains and DNA has been operating on the basis of the SSC VB "Vector".

For more than seven years, the Ethical and Bioethical Committees have been operating at the SSC VB Vector, whose main task is to conduct an examination of international and Russian biomedical research in order to protect the rights, interests, dignity and safety of a person who voluntarily takes part in these research.

Since the beginning of 2005, a laboratory for work with highly pathogenic strains of influenza virus, including avian influenza viruses, has been organized at the Center as part of the Department of Zoonotic Infections and Influenza. In accordance with the Order of Rospotrebnadzor dated May 10, 2007 No. 144, an industrial scientific and methodological center for reference diagnostics and study of highly pathogenic strains of the influenza virus was created on the basis of the State Scientific Center of VB "Vector". A WHO reference laboratory for the diagnosis of influenza H5N1 has been created and is successfully operating on the basis of the FBSI GN VB "Vector". For the second year, work is underway to secure the Center as a WHO Collaborating Center for Influenza (candidate WHO CC since 2009)

In the structure of SSC VB "Vector" there are expeditionary groups for collecting samples from outbreaks of infectious diseases, which successfully work in the outbreaks of avian influenza and other zooanthroponotic infections. Highly qualified specialists of "Vector" are involved in the operative examination of samples and confirmation of diagnoses in case of outbreaks of diseases of unknown etiology on the territory of Russia.

The scientific potential of the SSC VB "Vector" is made up of highly qualified specialists in the field of virology, molecular biology, genetic and cell engineering, epidemiology and biotechnology. The staff of the center is 1614 people, of which 139 are doctors and candidates of sciences.

The unique property of the Center is highly qualified scientific and engineering personnel and laboratory and experimental base, which allows conducting research with viruses pathogenic for humans and animals in complete safety for personnel and the environment.

In-depth research by scientists and specialists of the Center has a significant impact on the scientific policy in Russia in the field of control of infectious diseases. Research in the field of molecular epidemiology of viral infections, the relationship between the structure and function of viral genomes, the mechanisms of pathogenesis of infectious diseases, including the study of the relationship between the genetic characteristics of the host and the viral agent and the characteristics of the infectious process, are important strategic directions that will undoubtedly provide concrete practical results in the future. in terms of prompt forecasting of outbreaks of "emerging" and "re-emerging" infections, as well as the creation of fundamentally new preventive and therapeutic drugs for public health.

(FBUN SSC VB "Vector")

short information

One of the largest virological and biotechnological centers in Russia. Fundamental research works are focused on obtaining new scientific knowledge in the field of molecular epidemiology, molecular biology, genetic and cellular engineering, biotechnology, nanobiotechnology, ecology and biological safety. Applied research is aimed at developing effective means and methods for the prevention, treatment and diagnosis of infectious diseases. Since 1997, the WHO Collaborating Center for the Diagnosis of Orthopoxvirus Infections and the Museum of Smallpox Virus Strains and DNA have been operating on the basis of the Vector State Scientific Center of VB. Since 2009, on the basis of the SSC VB "Vector" there has been a WHO reference laboratory for the diagnosis of H5 influenza, the only one in Russia and one of 13 in the world.

The mission of the Center is scientific and practical support for countering global biological threats.

Founded (created)

The Center was founded in 1974. In 1994, by Decree of the Government of the Russian Federation No. 247 of March 29, 1994, the status of the State Scientific Center of the Russian Federation was assigned, confirmed to the present by the relevant regulatory acts of the Government of the Russian Federation (1997, 2000, 2002, 2004, 2007, 2009, 2011, 2013).

Work in priority areas and critical technologies for the development of science, technology and technology

The work is carried out in the priority areas of science, technology and technology of the Russian Federation: "Security and countering terrorism", "Science and Life" and on critical technologies: "Biocatalytic, biosynthetic and biosensor technologies", "Biomedical and veterinary technologies", "Genomic, proteomic and post-genomic technologies ”,“ Cellular technologies ”,“ Nano-, bio-, information, cognitive technologies ”,“ Bioengineering technologies ”.

Participation in the implementation of technology platforms

FBUN SSC VB "Vector" is a member of the Technology Platform "Medicine of the Future" and the Technology Platform "Technologies for Environmental Development".

Innovative projects

Multiplex test systems for detecting infections transmitted through tick and mosquito bites, multiplex test systems for detecting more than 10 intestinal infections, cultural, recombinant and DNA vaccines against socially significant and especially dangerous viral diseases, including variola virus, polyepitope vaccines against HIV / AIDS and other infectious diseases of humans and animals, new methods of delivery of vaccines and drugs (tableted, microencapsulated, nanomicrocapsulated), antiviral and anticancer drugs, new methods of differential diagnosis of somatic diseases using dielectrophoresis, mathematical models of the spread of epidemics of infectious diseases.

Research experimental base

A unique scientific and experimental base for conducting research with the viruses most dangerous to humans, including those for which there are no means of treatment and specific prophylaxis, in complete safety for the working personnel and the environment. Modern equipment for molecular biological, diagnostic, biotechnological, aerosol research. Availability of a site for the production of vaccine preparations, a site for the production of nutrient media, measles vaccine in accordance with GMP requirements, as well as pilot sites for the production of pilot batches of vaccines and drugs under development.

Patents, certificates

178 active patents of the Russian Federation, 4 useful models, 20 certificates.

R&D staff

Availability of Agreements with higher education institutions

Novosibirsk Medical University;

Novosibirsk State University;

Altai State University;

Novosibirsk State Agrarian University;

National Research Tomsk Polytechnic University.

Basic departments, scientific schools

The Center has four leading scientific and pedagogical schools: microbiology, immunology and virology, genetic engineering, biotechnology. There is an agreement with the Altai State University on the creation of a basic department "biopharmaceuticals based on recombinant technologies".

Main partners

Carries out scientific cooperation with institutions of the Russian Academy of Sciences, the Siberian Branch of the Russian Academy of Sciences, the Russian Academy of Medical Sciences, the Siberian Branch of the Russian Academy of Medical Sciences, the Siberian Branch of the Russian Academy of Agricultural Sciences, research institutions of Rospotrebnadzor, the State Scientific Center of the Russian Federation, higher educational institutions and pharmaceutical enterprises.

International scientific and technical cooperation

Cooperation:

With WHO on influenza as a member of the WHO Global Influenza Surveillance and Response System;

With WHO as experts on the WHO Advisory Committee on the Study of Smallpox Virus;

Centers for Disease Control and Prevention (CDC, Atlanta, USA); - with the WHO Reference Laboratory for influenza H5 subtype (Hong Kong, China);

With the WHO Collaborating Center for the Study of the Ecology of Influenza in Animals and Birds (Memphis, USA);

The WHO Collaborating Center for Reference Diagnostics and Research on Influenza (London, UK);

With the North-West Institute of Biology of the Plateau of the Chinese Academy of Sciences, with the Beijing Institute of Biological Sciences of the Chinese Academy of Sciences, with the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan, with the national influenza centers of the CIS countries (Kazakhstan, Kyrgyzstan, Azerbaijan, Belarus, Uzbekistan, Tajikistan).

Since August 2014, in the Republic of Guinea, as part of the ongoing work to assist West African countries in the fight against Ebola virus disease (EVD), a Russian laboratory began operating on the basis of a mobile complex of the specialized anti-epidemic brigade of Rospotrebnadzor.